A bipolar Ph.D. neuroscientist explores the neural basis of suicidal thoughts and behaviors — The shocking suicide of attorney and former Miss USA Cheslie Kryst a little over a month ago has prompted renewed attention to mental health issues, both generally and within the legal profession. I know the pressures of the job. …

Individualized neuromodulation could help sufferers of major depression who don’t respond to traditional treatments. — As the doctor gave her a physical exam, Mary* was unable to maintain eye contact. Although her depression had left her with a limited range of emotions, she still struggled to keep from crying. “Restricted and tearful affect,” wrote the examining physician. The results of her physical examination and routine…

If you don’t have carbs on you you’re no good to me — Like many people in the time of COVID-19, I’d put on a few pounds. I’d gone beyond adding my normal layer of winter padding to having to rotate between the two outfits I had left that fit. And when I say they didn’t fit, I mean they physically hurt to…

And shame on you for suggesting them. — You’ve seen the articles. “15 Foods That Are Bad for You,” or “Stop Eating This You Fat Slob.” They’re usually written by a registered dietitian or nutritionist and contain such groundbreaking revelations as “too much sugar is bad for you,” and “bacon is a bullet that you eat.” They then…

Categorization of antidepressants based on mitochondrial energetics has clinical value. — When I was diagnosed with bipolar I disorder, I was in the midst of a severe manic episode with psychotic features. I was rail-thin and exercising fanatically-even in the middle of the night at a 24-hour gym. I slept as little as 15 minutes a night, and when I did…

How the pandemic put additional strain on an already overburdened system. — Like many states, North Carolina is in the midst of a crisis in its mental healthcare system. …

A guided mindfulness-based stress reduction program was found to be comparable in efficacy to Escitalopram (Lexapro®) for treating anxiety disorders. — Deep inside our brains lies an almond-shaped structure called the amygdala. It lies at the center of primordial circuitry designed to help us respond to danger. Unfortunately, the same circuitry that primed our hominid ancestors for responding to a lion jumping out of the brush now kicks off the same…

Professor Remus Lupin’s lycanthropy is an apt metaphor for bipolar disorder — It’s Halloween again. When thoughts turn to witches, ghosts, and fantastic creatures. The sorts of preternatural beings that make up the world of Harry Potter. And among them, one of my favorite characters: Remus Lupin. Lupin is a wizard who was attacked by a werewolf as a child. The attack…

A subclass of adrenergic agonists provide pain relief without addiction or sedation. — Earlier this year, the U.S. Food and Drug Administration (FDA) took steps to foster the development of non-addictive alternatives to opioids by issuing a draft guidance to companies developing non-opioid analgesics with recommendations for how to best approach their drug development and labeling strategies. “Opioid misuse and abuse remain a…